Table S1
Ontology	Revigo cluster	Mean cluster structural coverage	Cluster members	Description	Mean structural coverage	#subVOGs	#Proteins
biological_process
	1	0.1410	GO:0006139	nucleobase-containing compound metabolic process	0.1410	1	2
	2	0.1410	GO:0006259	DNA metabolic process	0.1410	1	2
	3	0.1410	GO:0006278	RNA-dependent DNA biosynthetic process	0.1410	1	2
	4	0.1410	GO:0006725	cellular aromatic compound metabolic process	0.1410	1	2
	5	0.1410	GO:0006807	nitrogen compound metabolic process	0.1410	1	2
	6	0.0689	GO:0008150	biological_process	0.0689	10	59
	7	0.1410	GO:0008152	metabolic process	0.1410	1	2
	8	0.1410	GO:0009058	biosynthetic process	0.1410	1	2
	9	0.1410	GO:0009059	macromolecule biosynthetic process	0.1410	1	2
	10	0.1130	GO:0009894	regulation of catabolic process	0.1130	4	12
	11	0.1410	GO:0009987	cellular process	0.1410	1	2
	12	0.1130	GO:0010506	regulation of autophagy	0.1130	4	12
			GO:0010508	positive regulation of autophagy	0.1130	4	12
	13	0.1130	GO:0010605	negative regulation of macromolecule metabolic process	0.1130	4	12
			GO:0009892	negative regulation of metabolic process	0.1130	4	12
			GO:0010629	negative regulation of gene expression	0.1130	4	12
	14	0.1130	GO:0010608	posttranscriptional regulation of gene expression	0.1130	4	12
	15	0.1410	GO:0018130	heterocycle biosynthetic process	0.1410	1	2
	16	0.1130	GO:0019222	regulation of metabolic process	0.1130	4	12
	17	0.1410	GO:0019438	aromatic compound biosynthetic process	0.1410	1	2
	18	0.1130	GO:0031325	positive regulation of cellular metabolic process	0.1130	4	12
			GO:0009893	positive regulation of metabolic process	0.1130	4	12
			GO:0009896	positive regulation of catabolic process	0.1130	4	12
			GO:0031329	regulation of cellular catabolic process	0.1130	4	12
			GO:0031331	positive regulation of cellular catabolic process	0.1130	4	12
			GO:0048522	positive regulation of cellular process	0.1130	4	12
	19	0.1130	GO:0032268	regulation of cellular protein metabolic process	0.1130	4	12
			GO:0006417	regulation of translation	0.1130	4	12
	20	0.1130	GO:0032879	regulation of localization	0.1130	4	12
	21	0.1130	GO:0034248	regulation of cellular amide metabolic process	0.1130	4	12
	22	0.1410	GO:0034641	cellular nitrogen compound metabolic process	0.1410	1	2
	23	0.1410	GO:0034645	cellular macromolecule biosynthetic process	0.1410	1	2
	24	0.1410	GO:0034654	nucleobase-containing compound biosynthetic process	0.1410	1	2
	25	0.1130	GO:0035821	modification of morphology or physiology of other organism	0.1130	4	12
	26	0.1130	GO:0039604	suppression by virus of host translation	0.1130	4	12
			GO:0019057	modulation by virus of host translation	0.1130	4	12
			GO:0039606	suppression by virus of host translation initiation	0.1130	4	12
			GO:0039611	suppression by virus of host translation initiation factor activity	0.1130	4	12
	27	0.0494	GO:0039690	positive stranded viral RNA replication	0.1130	4	12
			GO:0019083	viral transcription	0.0113	4	42
			GO:0039689	negative stranded viral RNA replication	0.0113	4	42
			GO:0039694	viral RNA genome replication	0.0621	8	54
	28	0.0113	GO:0039696	RNA-templated viral transcription	0.0113	4	42
	29	0.0190	GO:0039697	negative stranded viral RNA transcription	0.0190	1	7
	30	0.1410	GO:0043170	macromolecule metabolic process	0.1410	1	2
	31	0.1130	GO:0044073	modulation by symbiont of host translation	0.1130	4	12
	32	0.1130	GO:0044092	negative regulation of molecular function	0.1130	4	12
	33	0.1410	GO:0044237	cellular metabolic process	0.1410	1	2
	34	0.1410	GO:0044238	primary metabolic process	0.1410	1	2
	35	0.1410	GO:0044249	cellular biosynthetic process	0.1410	1	2
	36	0.1410	GO:0044260	cellular macromolecule metabolic process	0.1410	1	2
	37	0.1410	GO:0044271	cellular nitrogen compound biosynthetic process	0.1410	1	2
	38	0.1130	GO:0044359	modulation of molecular function in other organism	0.1130	4	12
			GO:0019048	modulation by virus of host morphology or physiology	0.1130	4	12
			GO:0019054	modulation by virus of host process	0.1130	4	12
			GO:0039506	modulation by virus of host molecular function	0.1130	4	12
			GO:0039507	suppression by virus of host molecular function	0.1130	4	12
			GO:0039519	modulation by virus of host autophagy	0.1130	4	12
			GO:0039520	induction by virus of host autophagy	0.1130	4	12
			GO:0039656	modulation by virus of host gene expression	0.1130	4	12
			GO:0039657	suppression by virus of host gene expression	0.1130	4	12
			GO:0044003	modification by symbiont of host morphology or physiology	0.1130	4	12
			GO:0044068	modulation by symbiont of host cellular process	0.1130	4	12
GO:0044362			negative regulation of molecular function in other organism	0.1130	4	12
GO:0051817			modification of morphology or physiology of other organism involved in symbiotic interaction	0.1130	4	12
GO:0052055			modulation by symbiont of host molecular function	0.1130	4	12
GO:0052056			negative regulation by symbiont of host molecular function	0.1130	4	12
GO:0052204			negative regulation of molecular function in other organism involved in symbiotic interaction	0.1130	4	12
GO:0052205			modulation of molecular function in other organism involved in symbiotic interaction	0.1130	4	12
39	0.1410	GO:0046483	heterocycle metabolic process	0.1410	1	2
40	0.1130	GO:0048518	positive regulation of biological process	0.1130	4	12
41	0.1130	GO:0048519	negative regulation of biological process	0.1130	4	12
42	0.1130	GO:0050794	regulation of cellular process	0.1130	4	12
		GO:0050789	regulation of biological process	0.1130	4	12
43	0.1130	GO:0051246	regulation of protein metabolic process	0.1130	4	12
44	0.0657	GO:0051701	interaction with host	0.1130	4	12
		GO:0016032	viral process	0.0609	9	57
		GO:0019079	viral genome replication	0.0621	8	54
		GO:0044403	symbiosis, encompassing mutualism through parasitism	0.0609	9	57
		GO:0044419	interspecies interaction between organisms	0.0609	9	57
		GO:0046755	viral budding	0.0510	1	3
		GO:0046765	viral budding from nuclear membrane	0.0510	1	3
45	0.0609	GO:0051704	multi-organism process	0.0609	9	57
46	0.1130	GO:0052038	modulation by symbiont of host intracellular transport	0.1130	4	12
		GO:0039522	suppression by virus of host mRNA export from nucleus	0.1130	4	12
47	0.1130	GO:0052230	modulation of intracellular transport in other organism involved in symbiotic interaction	0.1130	4	12
48	0.1130	GO:0060341	regulation of cellular localization	0.1130	4	12
		GO:0032386	regulation of intracellular transport	0.1130	4	12
		GO:0051049	regulation of transport	0.1130	4	12
49	0.1130	GO:0065007	biological regulation	0.1130	4	12
50	0.1130	GO:0065009	regulation of molecular function	0.1130	4	12
51	0.1410	GO:0071704	organic substance metabolic process	0.1410	1	2
52	0.1410	GO:0071897	DNA biosynthetic process	0.1410	1	2
53	0.1410	GO:0090304	nucleic acid metabolic process	0.1410	1	2
54	0.1410	GO:1901360	organic cyclic compound metabolic process	0.1410	1	2
55	0.1410	GO:1901362	organic cyclic compound biosynthetic process	0.1410	1	2
56	0.1410	GO:1901576	organic substance biosynthetic process	0.1410	1	2
57	0.1130	GO:2000112	regulation of cellular macromolecule biosynthetic process	0.1130	4	12
		GO:0009889	regulation of biosynthetic process	0.1130	4	12
		GO:0010468	regulation of gene expression	0.1130	4	12
		GO:0010556	regulation of macromolecule biosynthetic process	0.1130	4	12
		GO:0031323	regulation of cellular metabolic process	0.1130	4	12
		GO:0031326	regulation of cellular biosynthetic process	0.1130	4	12
		GO:0051171	regulation of nitrogen compound metabolic process	0.1130	4	12
		GO:0060255	regulation of macromolecule metabolic process	0.1130	4	12
		GO:0080090	regulation of primary metabolic process	0.1130	4	12
molecular_function
	58	0.2260	GO:0001681	sialate O-acetylesterase activity	0.2260	1	2
			GO:0008126	acetylesterase activity	0.2260	1	2
	59	0.1195	GO:0003674	molecular_function	0.1195	4	11
	60	0.1480	GO:0003824	catalytic activity	0.1480	3	9
	61	0.1930	GO:0004518	nuclease activity	0.1930	1	2
			GO:0004519	endonuclease activity	0.1930	1	2
	62	0.0340	GO:0005488	binding	0.0340	1	2
	63	0.0250	GO:0016740	transferase activity	0.0250	1	5
	64	0.0250	GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0250	1	5
	65	0.0250	GO:0016779	nucleotidyltransferase activity	0.0250	1	5
	66	0.2095	GO:0016787	hydrolase activity	0.2095	2	4
	67	0.2095	GO:0016788	hydrolase activity, acting on ester bonds	0.2095	2	4
	68	0.0250	GO:0034062	5'-3' RNA polymerase activity	0.0250	1	5
			GO:0003968	RNA-directed 5'-3' RNA polymerase activity	0.0250	1	5
			GO:0097747	RNA polymerase activity	0.0250	1	5
	69	0.2260	GO:0034338	short-chain carboxylesterase activity	0.2260	1	2
	70	0.2260	GO:0052689	carboxylic ester hydrolase activity	0.2260	1	2